Curcumin can improve liver cirrhosis
Curcumin long-term treatment can reduce portal pressure and heart index in cirrhotic rats, and increase systemic vascular resistance. In the visceral system, curcumin can reduce the blood flow of the superior mesenteric artery (SMA), increase the vascular resistance of the SMA, and reduce the abnormal angiogenesis of the mesenteric blood vessels. Short-term treatment with curcumin can significantly induce visceral vasoconstriction. The expression levels of proteins such as phosphorylated-eNOS, COX2, VEGF, phosphorylated-VEGFR2 and phosphorylated-Erk in the mesentery also decreased. In the collateral circulation system, curcumin can induce collateral vasoconstriction and reduce portosystemic shunt.
Researchers believe that long-term treatment with curcumin can improve portal hypertension and portosystemic shunt in cirrhotic rats. Curcumin induces vasoconstriction by inhibiting the production of phosphorylated-eNOS, reduces mesenteric angiogenesis by blocking the VEGF pathway, and reduces visceral hyperdynamic circulation.
"Source: Yinuo Medical" https://www.ulabmed.com/content-134 -2571-1.html
